Is it safe to take Unisom and B6 every night while pregnant?
The American College of Obstetricians and Gynecologists (ACOG) state that it is safe for women to take vitamin B-6 and doxylamine, either separately or as Diclegis, during pregnancy and that this combination has “no harmful effects on the fetus.”
MEDS: Benadryl 25-50mg at bedtime, Vitamin B6 25-50mg orally 3 times a day. *Or can try the following instructions for Unisom/B6. 25mg of Vitamin B6 Instructions: Unisom 12.5mg (half of 25mg) and 25mg Vitamin B6 at NIGHT. If that is NOT effective INCREASE Unisom to 25mg (1 full tablet) and 25mg of Vitamin B6 at NIGHT.
From an FDA perspective, Unisom has been generally considered safe for pregnant women.
There has been no sign of harm to the fetus with vitamin B6 use. A typical dose of vitamin B6 for morning sickness is 10 mg to 25 mg, 3 times a day. Talk to your health professional before you take vitamin B6 for morning sickness.
If you experience any of the following symptoms, stop taking vitamin B6 and Unisom and call your doctor immediately: blurred vision, dilated pupils, or other vision problems. painful urination or difficulty urinating. erratic or fast heartbeat.
There has been no sign of harm to the fetus with vitamin B6 use. A typical dose of vitamin B6 for morning sickness is 10 mg to 25 mg, 3 times a day. Talk to your health professional before you take vitamin B6 for morning sickness. Intake of more than 100 mg a day of vitamin B6 can cause temporary nerve damage.
Pregnant woman can be given tablets of vitamin B6 to help boost their own levels. It's recommended that you only need to take 25 mg, three times a day (up to 200 mg of vitamin B6 a day can be used to treat morning sickness).
You can also take ½ of a Unisom tablet twice a day. Unisom is an over the counter sleeping preparation that is OKAY in pregnancy, and can help with nausea. (Make sure active ingredient is Doxylamine Succinate.)
Unisom Sleep Gels is only for short-term use until your symptoms clear up. Taking too much Unisom Sleep Gels can lead to serious heart problems, seizures, coma, or death.
Can I take Unisom every night? No. Unisom is intended as a temporary sleep aid and should not be taken for more than two weeks. 3 If you need ongoing help falling asleep, speak to your healthcare provider.
Can B6 cause birth defects?
Research from the National Library of Medicine reports that there appears to be no association between excessive Vitamin B6 and birth defects or malformations.
According to the FDA and the CDC, there is not enough evidence to suggest that taking Unisom during pregnancy raises the risk of birth defects, miscarriage, or pregnancy loss. The side effects of Unisom are typically mild, ranging from dry mouth to headache, nervousness, and congestion.

Having low vitamin B6 levels during pregnancy is highly unlikely to cause a miscarriage. While some studies have shown that having low vitamin B6 levels alongside low folate and vitamin B12 levels may increase the risk of miscarriage, it's unlikely that low vitamin B6 levels will increase the risk.
Several over-the-counter medications for sleep are considered safe during pregnancy. The antihistamines diphenhydramine and doxylamine are fine to take in recommended doses during pregnancy, even for extended periods. These are the ingredients found in Benadryl, Diclegis, Sominex, and Unisom.
Can doxylamine (Unisom SleepTabs) be used long term? This medication should only be used for short-term (2 weeks) treatment.
Drowsiness, dizziness, headache, constipation, stomach upset, blurred vision, decreased coordination, or dry mouth/nose/throat may occur. If any of these effects last or get worse, contact your doctor or pharmacist promptly.
Both Unisom (doxylamine) and B6 are safe throughout pregnancy, including in the first trimester. Although very people (about 1%) get hyperemesis gravidarum, the most severe form of morning sickness, even mild or moderate morning sickness can make life downright miserable.
Tips to ease the symptoms of morning sickness
75mg of vitamin B6 taken daily has been found in several randomised controlled trials to reduce the frequency and severity of nausea and vomiting in pregnancy.
Taking a supplement of vitamin B6 (10 mg 3-4 times daily) may be helpful, although it can take up to a week to experience results.
For some women, taking vitamin B6 supplements does appear to improve their morning sickness. However, experts aren't sure how much vitamin B6 is safe in pregnancy, so it's not routinely recommended as a treatment.
What does vitamin B6 do for fetus?
Vitamin B-6 (pyridoxine) plays a part in your growing baby's brain and nervous system development. It also is vital for producing norepinephrine and serotonin. These are two important neurotransmitters (signal messengers). Pyridoxine can help ease pregnancy symptoms of nausea and vomiting.
The US authorities set the no-observed-adverse-effect-level at 200 mg per day and the safe upper limit at 100 mg per day. A report of neurotoxicity in 2 patients who had taken 24 mg and 40 mg of vitamin B6 per day respectively, may be coincidence rather than a true toxic effect of such relatively low doses.
“In general, antihistamines [like Unisom] are safe in pregnancy,” confirmed Dr. Shirazian.
1. For mild nausea without vomiting, Vitamin B6 (pyridoxine) 25mg by mouth 3 times a day. 3. If no relief after 4-5 days, try Unisom 25mg (1 tablet) by mouth at bedtime and 12.5mg (1/2 tablet) in the morning and in the midafternoon along with Vitamin B6 three times a day.
Melatonin: Melatonin is considered one of the safest over-the-counter sleep aids, with few side effects. A prescription drug called ramelteon is designed to mimic the effects of melatonin. Like melatonin, it is not considered habit-forming and it does not affect balance.
Medication for Nausea and Vomiting
Diclegis or B6 (Pyridoxine) and Unisom (Doxylamine) are the only FDA approved drugs for n/v in pregnancy. Phenergan may be prescribed to you if this medication does not work.
Diphenhydramine also causes drowsiness, and can be used by adults and children 12 years of age and older who occasionally have trouble sleeping (insomnia). The effects of diphenhydramine can last for up to 6 hours. If you have trouble sleeping, do not take this medication for more than a few nights in a row.
If no relief after 4-5 days, try Unisom 25mg (1 tablet) by mouth at bedtime and 12.5mg (1/2 tablet) in the morning and in the midafternoon along with Vitamin B6 three times a day. May also increase Vitamin B6 to 50mg at bedtime with 25mg in morning and midafternoon if needed. Unisom can cause drowsiness.
The answer—not really. While your doctor may be able to suggest one that's relatively safe, there generally aren't any sleeping pills out there that are recommended for pregnant women. In fact, some studies have even found that sleeping pills can cause long-term problems for baby.
Sleep medicines are advised against using during pregnancy, but there are other medicines and home remedies that can help you sleep. These include over-the-counter medicines (antihistamines), herbal remedies (ginseng, honey, nutmeg), melatonin, and prescription medications.
Can you take Unisom every night?
Can I take Unisom every night? No. Unisom is intended as a temporary sleep aid and should not be taken for more than two weeks. 3 If you need ongoing help falling asleep, speak to your healthcare provider.
Unisom Sleep Gels is only for short-term use until your symptoms clear up. Taking too much Unisom Sleep Gels can lead to serious heart problems, seizures, coma, or death.
Several over-the-counter medications for sleep are considered safe during pregnancy. The antihistamines diphenhydramine and doxylamine are fine to take in recommended doses during pregnancy, even for extended periods. These are the ingredients found in Benadryl, Diclegis, Sominex, and Unisom.
Both Unisom (doxylamine) and B6 are safe throughout pregnancy, including in the first trimester. Although very people (about 1%) get hyperemesis gravidarum, the most severe form of morning sickness, even mild or moderate morning sickness can make life downright miserable.
Dr. Zanotti reassures expectant mothers not to stress if they accidentally find themselves on their backs for a brief spell. “We do know that short periods of time ― even if you were on your back for an hour or two ― probably do no harm to your child,” she says.
Regarding over-the-counter products, the active ingredient of over-the-counter sleep aids like Tylenol PM, Benadryl and Unisom is diphenhydramine, an antihistamine. It is generally safe and non-addicting.